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    Analysis of Mannitol Using RID-20A Differential Index Detector

    Mannitol possesses characteristics that include low moisture absorption and low reactivity, and is therefore used as an excipient for pharmaceuticals. USP methods for D-mannitol (hereafter, "mannitol") were amended in 2014 to specify the use of refractive index detection with a 7.8 mm × 300 mm L19 column.
    The RID-20A differential refractive index detector features an optical system with dual temperature control to absorb the impact of subtle changes in temperature, thereby permitting chromatograms to be generated with a stable baseline. Here, we introduce an example of mannitol analysis using the RID-20A.

     
    Structure of D-Mannitol

    Structure of D-Mannitol

     

    Chromatograms of a Standard Mixture of Four Sugar Alcohols

    Chromatograms of a Standard Mixture of Four Sugar Alcohols

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    RID-20A

    RID-20A